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Tirzepatide is not appropriate for individuals with a history of medullary thyroid carcinoma, MEN2 syndrome, severe gastroparesis, or certain endocrine conditions

Ibrahim & El Afandi, 2020

Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPAR signature

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The degradation of FPN, mediated by the E3 ubiquitin ligase RNF217, leads to intracellular iron accumulation, thereby increasing susceptibility to ferroptosis ( Therapeutic approaches to prevent FPN degradation may hold promise for mitigating OA progression